BDBM194494 US9200020, Table 3 compound 3

SMILES COC(=O)CCCN(CCn1c[nH]c2c1nc(N)[nH]c2=O)CCP(O)(O)=O

InChI Key InChIKey=ZPFRODFLLYKHSO-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 194494   

TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
The University Of Queensland

US Patent
LigandPNGBDBM194494(US9200020, Table 3 compound 3)
Affinity DataKi:  100nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
The University Of Queensland

US Patent
LigandPNGBDBM194494(US9200020, Table 3 compound 3)
Affinity DataKi:  1.30E+3nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine phosphoribosyltransferase(Plasmodium vivax)
The University Of Queensland

US Patent
LigandPNGBDBM194494(US9200020, Table 3 compound 3)
Affinity DataKi: >2.00E+5nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In DepthDetails US Patent