BDBM194958 US9206198, 11
SMILES CO[C@@H](CN1CCC2(CCN(C2=O)C2=CC(=O)OC2C)CC1)c1ccc2C(=O)OCc2c1C
InChI Key InChIKey=PNZDFESIWKDHOG-MRNPHLECSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 194958
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 20nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage
clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the
IonWorks ...More data for this Ligand-Target Pair
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 120nMT: 2°CAssay Description:The ROMK channel functional thallium flux assay is performed in 384
wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in
Poly-D...More data for this Ligand-Target Pair