BDBM19545 (2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4-methyl-2-[(3-methylphenyl)formamido]pentanamide::CHEMBL64765::arylaminoethyl amide, 1

SMILES COc1ccc(NCCNC(=O)[C@H](CC(C)C)NC(=O)c2cccc(C)c2)cc1

InChI Key InChIKey=BCHIMBJKORTZTR-NRFANRHFSA-N

Data  6 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 19545   

TargetProcathepsin L(Homo sapiens (Human))
Gnf

LigandPNGBDBM19545((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4-methyl-...)
Affinity DataKi:  7.20nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Gnf

LigandPNGBDBM19545((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4-methyl-...)
Affinity DataKi:  26nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gnf

LigandPNGBDBM19545((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4-methyl-...)
Affinity DataKi:  43nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Gnf

LigandPNGBDBM19545((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4-methyl-...)
Affinity DataKi:  62nM ΔG°:  -10.2kcal/molepH: 5.5 T: 2°CAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Gnf

LigandPNGBDBM19545((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4-methyl-...)
Affinity DataKi:  68nM ΔG°:  -10.2kcal/molepH: 5.5 T: 2°CAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gnf

LigandPNGBDBM19545((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4-methyl-...)
Affinity DataKi:  91nMAssay Description:The recombinant human cathepsin enzyme was preincubated with inhibitor for 20 minutes prior to addition of substrate. The substrate hydrolysis was mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Gnf

LigandPNGBDBM19545((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4-methyl-...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against recombinant human cathepsin S activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Gnf

LigandPNGBDBM19545((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4-methyl-...)
Affinity DataIC50:  372nMAssay Description:Inhibitory activity against recombinant human cathepsin K activity using fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Gnf

LigandPNGBDBM19545((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4-methyl-...)
Affinity DataIC50: <32nMAssay Description:Inhibitory activity against recombinant human cathepsin L activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed