BindingDB logo
myBDB logout

BDBM196529 US9212165, 80

SMILES: Cc1ccc(cn1)C#CC12CC3CC(CC(C3)(C1)NC(=O)c1cnccn1)C2

InChI Key: InChIKey=QXYBUVLJWXHUMM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 196529   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM196529
PNG
(US9212165, 80)
Show SMILES Cc1ccc(cn1)C#CC12CC3CC(CC(C3)(C1)NC(=O)c1cnccn1)C2
Show InChI InChI=1S/C23H24N4O/c1-16-2-3-17(13-26-16)4-5-22-9-18-8-19(10-22)12-23(11-18,15-22)27-21(28)20-14-24-6-7-25-20/h2-3,6-7,13-14,18-19H,8-12,15H2,1H3,(H,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 700n/an/an/an/a7.4n/a



H. Lundbeck A/S

US Patent


Assay Description
The rmGluR5 or hmGluR5 was stably expressed in a HEK 293 cell line and gown in Dulbecco's Modified Eagle Medium (DMEM) (Invitrogen, Carlsbad, Cal...


US Patent US9212165 (2015)


BindingDB Entry DOI: 10.7270/Q2Z89B69
More data for this
Ligand-Target Pair