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BDBM197716 US9216984, 1

SMILES: CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12

InChI Key:

Data: 6 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 197716   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1 [837-1142]


(Homo sapiens (Human))
BDBM197716
PNG
(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.90n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142]


(Homo sapiens (Human))
BDBM197716
PNG
(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.340n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM197716
PNG
(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.290n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM197716
PNG
(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [828-1132]


(Homo sapiens (Human))
BDBM197716
PNG
(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.260n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [837-1142]


(Homo sapiens (Human))
BDBM197716
PNG
(US9216984, 1)
Show SMILES CCCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.630n/an/an/an/a7.825



Incyte Corporation

US Patent


Assay Description
The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...


US Patent US9216984 (2015)


BindingDB Entry DOI: 10.7270/Q26M35PV
More data for this
Ligand-Target Pair