BDBM197717 US9216984, 2

SMILES CCCCC(CC#N)n1cc(cn1)-c1ncnc2[nH]ccc12

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 197717   

TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM197717(US9216984, 2)
Affinity DataIC50:  1.80nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM197717(US9216984, 2)
Affinity DataIC50:  0.570nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM197717(US9216984, 2)
Affinity DataIC50:  0.650nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM197717(US9216984, 2)
Affinity DataIC50:  1.40nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [828-1132](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM197717(US9216984, 2)
Affinity DataIC50:  0.300nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [837-1142](Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM197717(US9216984, 2)
Affinity DataIC50:  2nMpH: 7.8 T: 2°CAssay Description:The compounds of the invention were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al.,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent