BindingDB logo
myBDB logout

BDBM199119 N-(4-(1-(4,6-bis(methylamino)-1,3,5-triazin-2-yl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)phenyl)-4-methylbenzenesulphonamide (8a)

SMILES: CNc1nc(NC)nc(n1)-n1nc(cc1-c1ccc(OC)cc1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1

InChI Key: InChIKey=AARZRTZBKURHBM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 199119   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Matrix metalloproteinase-9 (MMP-9)


(Rattus norvegicus (Rat))
BDBM199119
PNG
(N-(4-(1-(4,6-bis(methylamino)-1,3,5-triazin-2-yl)-...)
Show SMILES CNc1nc(NC)nc(n1)-n1nc(cc1-c1ccc(OC)cc1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C28H28N8O3S/c1-18-5-15-23(16-6-18)40-39-38-35-21-11-7-19(8-12-21)24-17-25(20-9-13-22(37-4)14-10-20)36(34-24)28-32-26(29-2)31-27(30-3)33-28/h5-17,35H,1-4H3,(H2,29,30,31,32,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 625n/an/an/an/a7.525



Zhejiang Hospital



Assay Description
where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a...


Chem Biol Drug Des 88: 756-765 (2016)


Article DOI: 10.1111/cbdd.12807
BindingDB Entry DOI: 10.7270/Q2ZW1JR4
More data for this
Ligand-Target Pair
Matrix metalloproteinase-2 (MMP-2)


(Rattus norvegicus (Rat))
BDBM199119
PNG
(N-(4-(1-(4,6-bis(methylamino)-1,3,5-triazin-2-yl)-...)
Show SMILES CNc1nc(NC)nc(n1)-n1nc(cc1-c1ccc(OC)cc1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C28H28N8O3S/c1-18-5-15-23(16-6-18)40-39-38-35-21-11-7-19(8-12-21)24-17-25(20-9-13-22(37-4)14-10-20)36(34-24)28-32-26(29-2)31-27(30-3)33-28/h5-17,35H,1-4H3,(H2,29,30,31,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 666n/an/an/an/a7.525



Zhejiang Hospital



Assay Description
where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a...


Chem Biol Drug Des 88: 756-765 (2016)


Article DOI: 10.1111/cbdd.12807
BindingDB Entry DOI: 10.7270/Q2ZW1JR4
More data for this
Ligand-Target Pair