BDBM200373 US9227969, 1B::US9629836, 1B

SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(C[C@H]1F)C(=O)CO)-c1ccc(Oc2ncccn2)cc1Cl

InChI Key InChIKey=WZZBNLYBHUDSHF-UFUCKMQHSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 200373   

TargetDual specificity mitogen-activated protein kinase kinase 1 [K97R](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM200373(US9227969, 1B | US9629836, 1B)
Affinity DataIC50:  138nMAssay Description:The radioactive filter binding assay is standardized using recombinant human activated BRAF (V599E) kinase (Cat No. 14-557) and kinase dead MEK1 (K97...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM200373(US9227969, 1B | US9629836, 1B)
Affinity DataIC50:  138nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent