BDBM200375 US10011599, Example 3::US9227969, 3::US9629836, 3

SMILES Cc1nc2cnc3cc(F)c(cc3c2n1C1CCN(CCO)CC1)-c1ccc(Oc2ncccn2)cc1Cl

InChI Key InChIKey=JMZQVIPBHJJZML-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 200375   

LigandPNGBDBM200375(US10011599, Example 3 | US9227969, 3 | US9629836, ...)
Affinity DataIC50:  104nMpH: 7.5Assay Description:A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An enzymatic cascade assay i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM200375(US10011599, Example 3 | US9227969, 3 | US9629836, ...)
Affinity DataIC50:  104nMAssay Description:[MEK1 1mM ATP IC50 uM] A BRAF-MEK-ERK cascade assay is used to evaluate the effects of these compounds as inhibitors of the MAP kinase pathway. An en...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity mitogen-activated protein kinase kinase 1 [K97R](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM200375(US10011599, Example 3 | US9227969, 3 | US9629836, ...)
Affinity DataIC50:  104nMAssay Description:The radioactive filter binding assay is standardized using recombinant human activated BRAF (V599E) kinase (Cat No. 14-557) and kinase dead MEK1 (K97...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent