BDBM200712 US9233086, 10A

SMILES CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccccc1)c1ccccc1

InChI Key InChIKey=BCIPILGGOSCOMC-MHZLTWQESA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 200712   

TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataKi: <1nMAssay Description:Displacement of 5-FAM labelled tracer from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase 2A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataKi: <1nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50:  2.90nMAssay Description:Binding affinity to WDR5 (unknown origin) fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50:  2.90nMAssay Description:Displacement of fluorescence-labelled Ac-ARA peptide from WDR5 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetWD repeat-containing protein 5(Homo sapiens (Human))
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of N-terminal His-tagged WDR5 (24 to 334 residues) (unknown origin) interaction with MLL1 assessed as displacement of 5-Lys-FAM peptide su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetWD repeat-containing protein 5 [24-334](Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50: <1.00E+3nMpH: 6.5 T: 2°CAssay Description:N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase 2A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200712(US9233086, 10A)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed