BDBM201611 2-methyl-3-((6-(piperidin-1-yl)pyridin-2-yl)methoxy)quinoxaline::Roche-Dataset for PDE10A, Compound 616::US9540384, 15

SMILES Cc1nc2ccccc2nc1OCc1cccc(n1)N1CCCCC1

InChI Key InChIKey=KGMXOILUFTUXEP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 201611   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM201611(2-methyl-3-((6-(piperidin-1-yl)pyridin-2-yl)methox...)
Affinity DataIC50:  1.69E+3nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM201611(2-methyl-3-((6-(piperidin-1-yl)pyridin-2-yl)methox...)
Affinity DataIC50:  1.68E+3nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 .mu.l contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent