BDBM202105 US9233983, C-2

SMILES CN1CCN(CC1)c1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1cccc(N2CCOc3cc(ccc3C2=O)C2CC2)c1CO

InChI Key InChIKey=DWGIODFOCVZNFA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 202105   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Advinus Therapeutics

US Patent
LigandPNGBDBM202105(US9233983, C-2)
Affinity DataIC50:  12nMAssay Description:The inhibition assays were performed using the generic tyrosine kinase assay kit from C is Bio (HTRF KinEASE-TK #62TK0PEB). The assay is based on t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Mus musculus)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM202105(US9233983, C-2)
Affinity DataIC50:  36nMAssay Description:Inhibition of C57BL/6J mouse BTK assessed as decrease in anti-mouse IgM antibody stimulated BCR mediated CD69 upregulation preincubated for 30 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Advinus Therapeutics

US Patent
LigandPNGBDBM202105(US9233983, C-2)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human full length BTK preincubated for 10 mins followed by Tk-biotin peptide substrate addition after 90 mins by TR-FRET as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed