BDBM20677 2-amino-5-benzyl-6-methyl-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one::Pyrrolo[3,2-d]pyrimidine analogue, 5

SMILES Cc1cc2nc(N)[nH]c(=O)c2n1Cc1ccccc1

InChI Key InChIKey=PTOPHNKCVGRPMB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 20677   

TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM20677(2-amino-5-benzyl-6-methyl-3H,4H,5H-pyrrolo[3,2-d]p...)
Affinity DataIC50: >3.90E+4nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM20677(2-amino-5-benzyl-6-methyl-3H,4H,5H-pyrrolo[3,2-d]p...)
Affinity DataIC50: >3.90E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM20677(2-amino-5-benzyl-6-methyl-3H,4H,5H-pyrrolo[3,2-d]p...)
Affinity DataIC50:  2.00E+4nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

LigandPNGBDBM20677(2-amino-5-benzyl-6-methyl-3H,4H,5H-pyrrolo[3,2-d]p...)
Affinity DataIC50: >3.90E+4nMAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM20677(2-amino-5-benzyl-6-methyl-3H,4H,5H-pyrrolo[3,2-d]p...)
Affinity DataIC50:  3.90E+3nMAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

LigandPNGBDBM20677(2-amino-5-benzyl-6-methyl-3H,4H,5H-pyrrolo[3,2-d]p...)
Affinity DataIC50: >3.90E+4nMAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed