BDBM207567 US9260440, 12::US9617273, Example 12
SMILES CN(C)c1ccc(cc1)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O
InChI Key InChIKey=ALGOIHLIEHFUAZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 207567
Affinity DataIC50: 25.6nMpH: 8.0Assay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of human PARP-1 catalytic domain (662 to 1011 residues) expressed in Escherichia coli BL21(DE3) cells pre-incubated for 30 mins before add...More data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Inhibition of PARP-1 in human HeLa cells incubated for 18 hrs in presence of H2O2More data for this Ligand-Target Pair
Affinity DataIC50: 2.56E+4nMAssay Description:PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...More data for this Ligand-Target Pair