BDBM207978 N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-3-(4-chlorophenyl)-5-hydroxy-1,5-dihydro-2H-pyrrol-2-one (1c)

SMILES CN1C(=O)C(=C(c2c[nH]c3cc(Cl)ccc23)C1(O)Cc1ccc(Cl)cc1)c1ccc(Cl)cc1

InChI Key

Data  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 207978   

TargetE3 ubiquitin-protein ligase Mdm2 [1-118,T47W](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM207978(N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1H-indol-3...)
Affinity DataKd:  1.87E+4nMpH: 7.4 T: 2°CAssay Description:MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2 [1-118](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM207978(N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1H-indol-3...)
Affinity DataKd:  5.10E+4nMpH: 7.4 T: 2°CAssay Description:Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed