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BDBM209034 US9243038, 6c

SMILES: NC(=O)CC[C@@H]1NC(=O)OC2CCC(N2)OC(=O)N[C@@H](CCCCNC(=O)[C@@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC1=O)C(N)=O

InChI Key: InChIKey=LDJXITHKGQINMY-UAZCXGOXSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 209034   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens (Human))
BDBM209034
PNG
(US9243038, 6c )
Show SMILES NC(=O)CC[C@@H]1NC(=O)OC2CCC(N2)OC(=O)N[C@@H](CCCCNC(=O)[C@@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC1=O)C(N)=O
Show InChI InChI=1S/C42H56N8O10/c43-33(51)19-18-30-39(55)47-32(23-25-9-3-1-4-10-25)40(56)46-31(24-26-14-16-28(17-15-26)36(52)27-11-5-2-6-12-27)38(54)45-22-8-7-13-29(37(44)53)48-41(57)59-34-20-21-35(50-34)60-42(58)49-30/h2,5-6,11-12,14-17,25,29-32,34-35,50H,1,3-4,7-10,13,18-24H2,(H2,43,51)(H2,44,53)(H,45,54)(H,46,56)(H,47,55)(H,48,57)(H,49,58)/t29-,30-,31+,32-,34?,35?/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 570n/an/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...


US Patent US9243038 (2016)


BindingDB Entry DOI: 10.7270/Q2MW2FZV
More data for this
Ligand-Target Pair