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BDBM209037 US9243038, 10

SMILES: CCCCC1NC(=O)[C@H](CCC(N)=O)NC(=O)\C=C\C(=O)N[C@@H](CCCCNC(=O)[C@@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC1=O)C(N)=O

InChI Key: InChIKey=DCXHBDBBXCZUFL-WFQYMVRASA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 209037   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens)
BDBM209037
PNG
(US9243038, 10)
Show SMILES CCCCC1NC(=O)[C@H](CCC(N)=O)NC(=O)\C=C\C(=O)N[C@@H](CCCCNC(=O)[C@@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC1=O)C(N)=O
Show InChI InChI=1S/C37H47N7O8/c1-2-3-11-27-36(51)44-29(22-23-13-15-25(16-14-23)33(48)24-9-5-4-6-10-24)35(50)40-21-8-7-12-26(34(39)49)41-31(46)19-20-32(47)42-28(37(52)43-27)17-18-30(38)45/h4-6,9-10,13-16,19-20,26-29H,2-3,7-8,11-12,17-18,21-22H2,1H3,(H2,38,45)(H2,39,49)(H,40,50)(H,41,46)(H,42,47)(H,43,52)(H,44,51)/b20-19+/t26-,27?,28-,29+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 1.50E+3n/an/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...


US Patent US9243038 (2016)


BindingDB Entry DOI: 10.7270/Q2MW2FZV
More data for this
Ligand-Target Pair