BDBM209334 US9266883, 98

SMILES COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc23)ncc1C#N

InChI Key InChIKey=ZTYSXMGILYNNJX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 209334   

TargetFibroblast growth factor receptor 4 [388-802](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM209334(US9266883, 98)
Affinity DataIC50:  0.400nMpH: 7.5 T: 2°CAssay Description:Liquid handling and incubation steps were done on an Innovadyne Nanodrop Express equipped with a robotic arm (Thermo CatX, Caliper Twister II) and an...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Southeast University

Curated by ChEMBL
LigandPNGBDBM209334(US9266883, 98)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) incubated for 60 mins by caliper microfluidic mobility shift technology based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM209334(US9266883, 98)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of recombinant non-phosphorylated FGFR4 kinase domain (442 to 753) (unknown origin) expressed in Sf9 insect cells using 5-Fluo-Ahx-KKKKEEI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM209334(US9266883, 98)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of FGFR4 in mouse BAF3 cells assessed as decrease in FGFR4 phosphorylation incubated for 40 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM209334(US9266883, 98)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of FGFR4 (unknown origin) incubated for 60 mins by caliper microfluidic mobility shift technology based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed