BDBM210036 US10576087, Compound 1.3::US9273046, 1.3

SMILES O=C1CCc2c(Oc3ccc4CC5C(C5c4c3)c3nc4ccccc4s3)ccnc2N1

InChI Key InChIKey=IXJJQTYDLOSUBW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 210036   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM210036(US10576087, Compound 1.3 | US9273046, 1.3)
Affinity DataIC50:  88nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM210036(US10576087, Compound 1.3 | US9273046, 1.3)
Affinity DataIC50:  5.5nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM210036(US10576087, Compound 1.3 | US9273046, 1.3)
Affinity DataIC50:  88nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM210036(US10576087, Compound 1.3 | US9273046, 1.3)
Affinity DataIC50:  5.5nMT: 2°CAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent