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BDBM212592 US9556111, Table 1.1::US9951033, Compound Table 1.1

SMILES: CC(C)(C)c1ccc(CN(Cc2nc(cs2)C(O)=O)Cc2ccc(F)cc2)cc1

InChI Key: InChIKey=CJGWWGSNPCVSNO-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 212592   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
A-kinase anchor protein 7 isoform gamma (AKAP-18)


(Mus musculus (Mouse))
BDBM212592
PNG
(US9556111, Table 1.1 | US9951033, Compound Table 1...)
Show SMILES CC(C)(C)c1ccc(CN(Cc2nc(cs2)C(O)=O)Cc2ccc(F)cc2)cc1
Show InChI InChI=1S/C23H25FN2O2S/c1-23(2,3)18-8-4-16(5-9-18)12-26(13-17-6-10-19(24)11-7-17)14-21-25-20(15-29-21)22(27)28/h4-11,15H,12-14H2,1-3H3,(H,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.16E+4n/an/an/an/a



UNIVERSITETET I OSLO

US Patent


Assay Description
Stable and optimal assay conditions were determined by cross-titrating GST-AKAP18 δ and biotinylated PLB using 10 μg/ml glutathione accepto...


US Patent US9951033 (2018)

More data for this
Ligand-Target Pair
A-kinase anchor protein 7 isoform gamma


(Homo sapiens (Human))
BDBM212592
PNG
(US9556111, Table 1.1 | US9951033, Compound Table 1...)
Show SMILES CC(C)(C)c1ccc(CN(Cc2nc(cs2)C(O)=O)Cc2ccc(F)cc2)cc1
Show InChI InChI=1S/C23H25FN2O2S/c1-23(2,3)18-8-4-16(5-9-18)12-26(13-17-6-10-19(24)11-7-17)14-21-25-20(15-29-21)22(27)28/h4-11,15H,12-14H2,1-3H3,(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 4.16E+4n/an/an/an/a



UNIVERSITETET I OSLO

US Patent


Assay Description
Stable and optimal assay conditions were determined by cross-titrating GST-AKAP18δ and biotinylated PLB using 10 μg/ml glutathione acceptor...


US Patent US9556111 (2017)


BindingDB Entry DOI: 10.7270/Q20Z758K
More data for this
Ligand-Target Pair