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BDBM212599 US9556111, Table 1.5::US9951033, Compound Table 1.3

SMILES: OC(=O)c1csc(CN(CCC(c2ccccc2)c2ccccc2)Cc2ccccc2F)n1

InChI Key: InChIKey=GZQBUCHFXQDBRR-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 212599   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
A-kinase anchor protein 7 isoform gamma (AKAP-18)


(Mus musculus (Mouse))
BDBM212599
PNG
(US9556111, Table 1.5 | US9951033, Compound Table 1...)
Show SMILES OC(=O)c1csc(CN(CCC(c2ccccc2)c2ccccc2)Cc2ccccc2F)n1
Show InChI InChI=1S/C27H25FN2O2S/c28-24-14-8-7-13-22(24)17-30(18-26-29-25(19-33-26)27(31)32)16-15-23(20-9-3-1-4-10-20)21-11-5-2-6-12-21/h1-14,19,23H,15-18H2,(H,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.06E+4n/an/an/an/a



UNIVERSITETET I OSLO

US Patent


Assay Description
Stable and optimal assay conditions were determined by cross-titrating GST-AKAP18 δ and biotinylated PLB using 10 μg/ml glutathione accepto...


US Patent US9951033 (2018)

More data for this
Ligand-Target Pair
A-kinase anchor protein 7 isoform gamma


(Homo sapiens (Human))
BDBM212599
PNG
(US9556111, Table 1.5 | US9951033, Compound Table 1...)
Show SMILES OC(=O)c1csc(CN(CCC(c2ccccc2)c2ccccc2)Cc2ccccc2F)n1
Show InChI InChI=1S/C27H25FN2O2S/c28-24-14-8-7-13-22(24)17-30(18-26-29-25(19-33-26)27(31)32)16-15-23(20-9-3-1-4-10-20)21-11-5-2-6-12-21/h1-14,19,23H,15-18H2,(H,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.06E+4n/an/an/an/a



UNIVERSITETET I OSLO

US Patent


Assay Description
Stable and optimal assay conditions were determined by cross-titrating GST-AKAP18δ and biotinylated PLB using 10 μg/ml glutathione acceptor...


US Patent US9556111 (2017)


BindingDB Entry DOI: 10.7270/Q20Z758K
More data for this
Ligand-Target Pair