BDBM213823 EPL-BS1246 (UDO)

SMILES FC(F)(F)c1ccc(cc1)N1CCN(CC1)C(=O)[C@@H](c1ccc(Cl)cc1)c1cccnc1

InChI Key InChIKey=OJFZYAQGMWSUID-QFIPXVFZSA-N

Data  6 IC50  3 Kd

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 213823   

TargetCytochrome P450 1A2(Human)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataIC50: >2.00E+4nMT: 37°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataIC50:  9.00E+3nMT: 37°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C19(Human)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataIC50:  1.20E+4nMT: 37°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataIC50:  4.00E+3nMT: 37°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Epichem

Curated by ChEMBL
LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as 6beta-hydroxylation of testosteroneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataKd:  19nMpH: 7.4 T: 37°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPutative lanosterol 14-alpha-demethylase(Leishmania infantum)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataKd:  156nMpH: 7.4 T: 37°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetLanosterol 14-alpha demethylase(Human)
Vanderbilt University

LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataKd:  69nMpH: 7.4 T: 37°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Epichem

Curated by ChEMBL
LigandPNGBDBM213823(EPL-BS1246 (UDO))
Affinity DataIC50:  2.00E+4nMT: 37°CAssay Description:Inhibition of hepatic cytochromes P450 was assessed in human liver microsomes using a substrate-specific approach of monitoring metabolites formed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed