BDBM21502 4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyrazol-3-yl]-2-(pyrrolidin-1-yl)quinoline::Dihydropyrrolopyrazole, 12

SMILES C1CCN(C1)c1cc(-c2c3CCCn3nc2-c2ccccn2)c2ccccc2n1

InChI Key InChIKey=JXGHHJQETWYELK-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21502   

TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM21502(4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyrazol...)
Affinity DataIC50: >2.00E+4nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed