BDBM21909 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[2-(1H-imidazol-4-yl)ethyl]amino}quinoline-3-carbonitrile::Cyanoquinoline, 22

SMILES Fc1ccc(Nc2c(cnc3c(Cl)cc(NCCc4cnc[nH]4)cc23)C#N)cc1Cl

InChI Key InChIKey=LZXQUGQUPHHSQR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21909   

TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21909(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[2-...)
Affinity DataIC50:  130nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed