BDBM21926 8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[({1-[3-(dimethylamino)propyl]-1H-1,2,3-triazol-4-yl}methyl)amino]quinoline-3-carbonitrile::Cyanoquinoline, 55

SMILES CN(C)CCCn1cc(CNc2cc(Br)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1

InChI Key InChIKey=RUCXDAGQSXXFMK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 21926   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21926(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[({1-...)
Affinity DataIC50: >5.00E+3nMAssay Description:EGFR kinase activity was assayed using poly(Glu4-Tyr) as a substrate. The phosphorylation of tyrosine residue was detected by an ELISA. IC50 calculat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21926(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[({1-...)
Affinity DataIC50:  20nMAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed