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BDBM21930 8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(4-ethyl-1H-imidazol-5-yl)methyl]amino}quinoline-3-carbonitrile::Cyanoquinoline, 41

SMILES: CCc1nc[nH]c1CNc1cc(Cl)c2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1

InChI Key: InChIKey=RJUOHHLNBQCCPS-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21930   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM21930
PNG
(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(4...)
Show SMILES CCc1nc[nH]c1CNc1cc(Cl)c2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1
Show InChI InChI=1S/C22H17Cl2FN6/c1-2-19-20(30-11-29-19)10-27-14-5-15-21(31-13-3-4-18(25)16(23)6-13)12(8-26)9-28-22(15)17(24)7-14/h3-7,9,11,27H,2,10H2,1H3,(H,28,31)(H,29,30)
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Similars

Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...


J Med Chem 50: 4728-45 (2007)

More data for this
Ligand-Target Pair