BDBM21970 3-[(4S,6R)-4,9-diamino-6-hydroxynonyl]-1-nitroguanidine::Hydroxyethylene derivative, 9

SMILES NCCC[C@@H](O)C[C@@H](N)CCCN=C(N)N[N+]([O-])=O

InChI Key InChIKey=JQJDNJUXEQFXTG-DTWKUNHWSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 21970   

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

LigandPNGBDBM21970(3-[(4S,6R)-4,9-diamino-6-hydroxynonyl]-1-nitroguan...)
Affinity DataKi:  830nM ΔG°:  -8.43kcal/mole IC50:  6.80E+3nMpH: 7.4 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

LigandPNGBDBM21970(3-[(4S,6R)-4,9-diamino-6-hydroxynonyl]-1-nitroguan...)
Affinity DataIC50:  3.13E+5nMpH: 7.4 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

LigandPNGBDBM21970(3-[(4S,6R)-4,9-diamino-6-hydroxynonyl]-1-nitroguan...)
Affinity DataIC50:  1.53E+6nMpH: 7.4 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed