BDBM222640 US9315491, MTR-0412::US9801888, Compound MTR-0412

SMILES CSc1c(Cl)nc(nc1N1CCOCC1)-c1ccc(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)cc1F

InChI Key InChIKey=UITHUPKOPFDCDB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 222640   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Development Center For Biotechnology

US Patent
LigandPNGBDBM222640(US9315491, MTR-0412 | US9801888, Compound MTR-0412)
Affinity DataIC50:  137nMAssay Description:The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Development Center For Biotechnology

US Patent
LigandPNGBDBM222640(US9315491, MTR-0412 | US9801888, Compound MTR-0412)
Affinity DataIC50:  137nMpH: 7.5Assay Description:The activity of the compound against mTOR was examined by measuring the incorporation of 33P from [γ-33P]-ATP into 4EBP1. His-tagged, recombina...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent