BDBM222818 US11059766, WO2011128279 Ex. 109::US9315498, 109

SMILES CN1[C@H]2CCC[C@H]2N(C1=O)c1ccc(cn1)C#Cc1cccc(F)c1

InChI Key InChIKey=CXSRRWDESYDWAM-ZWKOTPCHSA-N

Data  1 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 222818   

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US11059766, WO2011128279 Ex. 109 | US9315498, 109)
Affinity DataKi:  37nMAssay Description:For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US11059766, WO2011128279 Ex. 109 | US9315498, 109)
Affinity DataEC50:  18nMAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US11059766, WO2011128279 Ex. 109 | US9315498, 109)
Affinity DataEC50:  18nMAssay Description:For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform 1 of Metabotropic glutamate receptor 5 (5a)(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US11059766, WO2011128279 Ex. 109 | US9315498, 109)
Affinity DataEC50:  18nMT: 2°CAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM222818(US11059766, WO2011128279 Ex. 109 | US9315498, 109)
Affinity DataEC50:  12nMAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu5a receptor was generated; for the work with mGlu5 Positive ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent