BDBM223281 2-(5-((Cyclopropylmethyl)(naphthalen-1-yl)amino)-4-methoxypyrimidine-2-carbonyl)cyclopropanecarboxylic acid::US20160326143, 56::US9657001, 56

SMILES COc1nc(ncc1N(CC1CC1)c1ccc(Cl)c2ccccc12)C(=O)C1CC1C(O)=O

InChI Key InChIKey=DDLXCVVUOUQRRH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 223281   

TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223281(2-(5-((Cyclopropylmethyl)(naphthalen-1-yl)amino)-4...)
Affinity DataIC50:  17nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM223281(2-(5-((Cyclopropylmethyl)(naphthalen-1-yl)amino)-4...)
Affinity DataIC50:  17nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent