BDBM223320 KDOAM-25

SMILES CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(N)=O

InChI Key InChIKey=PNFMVADNCOGWME-UHFFFAOYSA-N

Data  32 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 223320   

TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  19nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5D(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  558nMAssay Description:Inhibition of KDM5D (unknown origin) in presence of 300 uM 2-OGMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  71nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  69nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5D(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  69nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  80nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  20nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  60nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5D(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  60nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3A(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  3.00E+4nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3B(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  8.00E+4nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  1.00E+4nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  5.00E+3nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 6B(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  1.00E+5nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  4.00E+4nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone lysine demethylase PHF8(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  1.00E+4nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal oxygenase 2(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: <1.00E+5nMAssay Description:KDOAM-25 was tested against a panel of 15 2-OG oxygenases (black text) including a representative from each of the lysine demethylases sub-families.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal oxygenase 1(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: <1.00E+5nMAssay Description:KDOAM-25 was tested against a panel of 15 2-OG oxygenases (black text) including a representative from each of the lysine demethylases sub-families.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha inhibitor(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: <1.00E+5nMAssay Description:MALDI-TOF enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50: <1.00E+5nMAssay Description:MALDI-TOF enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataKd:  2.70E+3nMAssay Description:Binding affinity to ARID/PHD1/Zn binding domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli by...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of ARID/PHD1 domain truncated human N-terminal His-SUMO-tagged KDM5A (1 to 588 residues) expressed in Escherichia coli using H3K4me3 as su...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of KDM5A (M1 to L801 residues) PHD2/3 deletion mutant (unknown origin) demethylation activity preincubated for 10 mins followed by peptide...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of KDM5A (M1 to L801 residues) PHD2/3 deletion mutant (unknown origin) demethylation activity preincubated for 10 mins followed by peptide...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  19nMAssay Description:Inhibition of KDM5B (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  27nMAssay Description:Inhibition of KDM5A (unknown origin) in presence of 4 uM 2-OGMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  558nMAssay Description:Inhibition of KDM5A (unknown origin) in presence of 300 uM 2-OGMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  27nMAssay Description:Inhibition of KDM5B (unknown origin) in presence of 4 uM 2-OGMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  558nMAssay Description:Inhibition of KDM5B (unknown origin) in presence of 300 uM 2-OGMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  27nMAssay Description:Inhibition of KDM5C (unknown origin) in presence of 4 uM 2-OGMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  558nMAssay Description:Inhibition of KDM5C (unknown origin) in presence of 300 uM 2-OGMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 5D(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  27nMAssay Description:Inhibition of KDM5D (unknown origin) in presence of 4 uM 2-OGMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM223320(KDOAM-25)
Affinity DataIC50:  4.80E+3nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed