BDBM22344 1,3-Diarylprop-2-yn-1-one, 13a::3-(4-methanesulfonylphenyl)-1-phenylprop-2-yn-1-one::CHEMBL193856

SMILES CS(=O)(=O)c1ccc(cc1)C#CC(=O)c1ccccc1

InChI Key InChIKey=OIHHELVXIPDXIK-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 22344   

TargetProstaglandin G/H synthase 1(Sheep)
University of Alberta

LigandPNGBDBM22344(1,3-Diarylprop-2-yn-1-one, 13a | 3-(4-methanesulfo...)
Affinity DataIC50:  1.00E+3nMpH: 8.0 T: 37°CAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLipoxygenase(Potato)
University of Alberta

LigandPNGBDBM22344(1,3-Diarylprop-2-yn-1-one, 13a | 3-(4-methanesulfo...)
Affinity DataIC50: >1.00E+4nMAssay Description:The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Human)
University of Alberta

LigandPNGBDBM22344(1,3-Diarylprop-2-yn-1-one, 13a | 3-(4-methanesulfo...)
Affinity DataIC50:  1.00E+4nMAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Sheep)
University of Alberta

LigandPNGBDBM22344(1,3-Diarylprop-2-yn-1-one, 13a | 3-(4-methanesulfo...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity against ovine cyclooxygenase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM22344(1,3-Diarylprop-2-yn-1-one, 13a | 3-(4-methanesulfo...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against 15-lipoxygenase obtained from soybeanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Sheep)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM22344(1,3-Diarylprop-2-yn-1-one, 13a | 3-(4-methanesulfo...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibitory activity against ovine cyclooxygenase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM22344(1,3-Diarylprop-2-yn-1-one, 13a | 3-(4-methanesulfo...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase obtained from potatoMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSeed linoleate 13S-lipoxygenase-1(Soybean)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM22344(1,3-Diarylprop-2-yn-1-one, 13a | 3-(4-methanesulfo...)
Affinity DataIC50: >1.00E+4nMAssay Description:The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed