BDBM223542 US9321748, 2
SMILES Nc1ncc(cc1-c1nnc(o1)C1CC1)-c1ccc2[nH]ccc2c1
InChI Key InChIKey=OYEFMLFXAJEYCF-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 223542
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527,G2019S](Homo sapiens (Human))
H. Lundbeck
US Patent
H. Lundbeck
US Patent
Affinity DataIC50: 1.00E+3nMpH: 8.5 T: 2°CAssay Description:The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
H. Lundbeck
Curated by ChEMBL
H. Lundbeck
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
H. Lundbeck
Curated by ChEMBL
H. Lundbeck
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant human wild type GST-tagged LRRK2 (970 to 2527 residues) preincubated for 30 mins followed by fluorescein-LRRKtide substrate...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [970-2527](Homo sapiens (Human))
H. Lundbeck
US Patent
H. Lundbeck
US Patent
Affinity DataIC50: 570nMpH: 8.5 T: 2°CAssay Description:The kinase reaction buffer consists of 50 mM Tris pH 8.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA, and 2 mM DTT. In the assay, 1 nM LRRK2 WT or 250 pM ...More data for this Ligand-Target Pair