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BDBM22595 3-[2-(4-tert-butylphenoxy)acetamido]benzoic acid::Compound DLC27

SMILES: CC(C)(C)c1ccc(OCC(=O)Nc2cccc(c2)C(O)=O)cc1

InChI Key: InChIKey=HBWHFUOANGBPBY-UHFFFAOYSA-N

Data: 1 IC50  1 ITC

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22595   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM22595
PNG
(3-[2-(4-tert-butylphenoxy)acetamido]benzoic acid |...)
Show SMILES CC(C)(C)c1ccc(OCC(=O)Nc2cccc(c2)C(O)=O)cc1
Show InChI InChI=1S/C19H21NO4/c1-19(2,3)14-7-9-16(10-8-14)24-12-17(21)20-15-6-4-5-13(11-15)18(22)23/h4-11H,12H2,1-3H3,(H,20,21)(H,22,23)
PDB

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PC cid
PC sid
UniChem

Patents


Similars

PubMed
n/an/a 2.90E+4n/an/an/an/an/an/a



Korea Research Institute of Bioscience and Biotechnology

Curated by ChEMBL


Assay Description
Inhibition of hypoxia induced HIF1 transcriptional activity in human Hep3B cells by cell-based HRE reporter assay


J Med Chem 50: 1675-84 (2007)

More data for this
Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 22595
Cell (A)Syringe (B)Cell
Links
Syringe
Links
Cell + Syr
Links
ΔG°
kcal/mole
-TΔS°
kcal/mole
ΔH°
kcal/mole
log KpHTemp
°C
HIV-1 Nef

(Human immunodeficiency virus type 1 (isolate BRU/L...)
BDBM22595
JPEG
(3-[2-(4-tert-butylphenoxy)acetamido]benzoic acid |...)
GoogleScholar
PDB
PC cid
PC sid
-8.17-7.41-0.7646.01725



Centre National de la Recherche Scientifique





Proc Natl Acad Sci U S A 104: 19256-61 (2007)