BDBM227594 PS10

SMILES Oc1ccc(c(O)c1)S(=O)(=O)N1Cc2cc(O)cc(O)c2C1

InChI Key InChIKey=SVUZJWAAXPEMKJ-UHFFFAOYSA-N

Data  11 IC50  3 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 227594   

Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataKd:  239nMpH: 7.5 T: 2°CAssay Description:The PDK2 or Hsp90 N-terminal domain protein was dialyzed against 1 liter of thedialysis buffer containing 50 mM Tris-Cl, pH 7.5, 50 mM KCl, 1 mM MgCl...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataEC50:  456nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SUMO-fused PDK2 expressed in Escherichia coli BL-21 cells preincubated for 15 mins followed by...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataIC50:  2.07E+3nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataIC50:  800nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataIC50:  2.13E+4nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataIC50:  770nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataIC50:  456nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataKd:  156nMAssay Description:Binding affinity to N-terminal His6-SUMO tagged recombinant human PDK2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM227594(PS10)
Affinity DataIC50:  4.70E+4nMAssay Description:Displacement of fluorescein-labelled VER160364 from HSP90A (unknown origin) after 90 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataIC50:  2.13E+4nMAssay Description:Binding affinity towards human Dopamine receptor D2 (long) by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataIC50:  2.10E+3nMAssay Description:Binding affinity towards human Dopamine receptor D2 (long) by [3H]-spiperone displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataIC50:  840nMAssay Description:Inhibition of [3H]citalopram binding to serotonin transporter (SERT) of cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataIC50:  800nMAssay Description:Inhibition of PDHK2 (unknown origin) assessed as decrease in phosphorylation of E1alpha subunit at serine 293 residue after 1 hr by DELFIAMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataIC50:  760nMAssay Description:Inhibition of PDK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha [1-236](Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227594(PS10)
Affinity DataKd:  4.70E+4nMpH: 7.5 T: 2°CAssay Description:The PDK2 or Hsp90 N-terminal domain protein was dialyzed against 1 liter of thedialysis buffer containing 50 mM Tris-Cl, pH 7.5, 50 mM KCl, 1 mM MgCl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed