BDBM227710 N-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methylthiophene-3-carboxamide::US9556157, 1

SMILES CCN(C1CCOCC1)c1scc(C(=O)NCc2c(C)[nH]c(C)cc2=O)c1C

InChI Key InChIKey=WQDGZGHOMAXVIX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227710   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Glaxosmithkline

US Patent
LigandPNGBDBM227710( N-((2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)me...)
Affinity DataIC50:  316nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent