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BDBM227732 3-bromo-n-(6-isopropoxy-1h-indazol-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine::US9556181, 17::US9556181, 18::US9556181, 20::US9556181, 21

SMILES: CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2[nH]nc(Br)c12

InChI Key: InChIKey=VUCOPDPBZGZUCX-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 227732   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase signal-integrating kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM227732
PNG
(3-bromo-n-(6-isopropoxy-1h-indazol-5-yl)-1h-pyrazo...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2[nH]nc(Br)c12
Show InChI InChI=1S/C15H14BrN7O/c1-7(2)24-11-4-9-8(5-19-21-9)3-10(11)20-14-12-13(16)22-23-15(12)18-6-17-14/h3-7H,1-2H3,(H,19,21)(H2,17,18,20,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
TBDA recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accessio...


US Patent US9556181 (2017)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM227732
PNG
(3-bromo-n-(6-isopropoxy-1h-indazol-5-yl)-1h-pyrazo...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2[nH]nc(Br)c12
Show InChI InChI=1S/C15H14BrN7O/c1-7(2)24-11-4-9-8(5-19-21-9)3-10(11)20-14-12-13(16)22-23-15(12)18-6-17-14/h3-7H,1-2H3,(H,19,21)(H2,17,18,20,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 27n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
TBDA recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accessio...


US Patent US9556181 (2017)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM227732
PNG
(3-bromo-n-(6-isopropoxy-1h-indazol-5-yl)-1h-pyrazo...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2[nH]nc(Br)c12
Show InChI InChI=1S/C15H14BrN7O/c1-7(2)24-11-4-9-8(5-19-21-9)3-10(11)20-14-12-13(16)22-23-15(12)18-6-17-14/h3-7H,1-2H3,(H,19,21)(H2,17,18,20,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 63n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
TBDA recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accessio...


US Patent US9556181 (2017)

More data for this
Ligand-Target Pair
MAP kinase signal-integrating kinase 1 (MKNK1)


(Homo sapiens (Human))
BDBM227732
PNG
(3-bromo-n-(6-isopropoxy-1h-indazol-5-yl)-1h-pyrazo...)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2[nH]nc(Br)c12
Show InChI InChI=1S/C15H14BrN7O/c1-7(2)24-11-4-9-8(5-19-21-9)3-10(11)20-14-12-13(16)22-23-15(12)18-6-17-14/h3-7H,1-2H3,(H,19,21)(H2,17,18,20,22,23)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 19n/an/an/an/a7.5n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
TBDA recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accessio...


US Patent US9556181 (2017)

More data for this
Ligand-Target Pair