BDBM22815 5-iodo-2,3-dihydro-1H-indole-2,3-dione::Isatin-based compound, 35

SMILES Ic1ccc2NC(=O)C(=O)c2c1

InChI Key InChIKey=OEUGDMOJQQLVAZ-UHFFFAOYSA-N

Data  5 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 22815   

TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
St. Jude Research Hospital

LigandPNGBDBM22815(5-iodo-2,3-dihydro-1H-indole-2,3-dione | Isatin-ba...)
Affinity DataKi:  1.16E+3nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22815(5-iodo-2,3-dihydro-1H-indole-2,3-dione | Isatin-ba...)
Affinity DataKi:  2.28E+4nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22815(5-iodo-2,3-dihydro-1H-indole-2,3-dione | Isatin-ba...)
Affinity DataKi:  2.69E+4nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22815(5-iodo-2,3-dihydro-1H-indole-2,3-dione | Isatin-ba...)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22815(5-iodo-2,3-dihydro-1H-indole-2,3-dione | Isatin-ba...)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-glutamine gamma-glutamyltransferase 2(Homo sapiens (Human))
Stanford University

Curated by ChEMBL
LigandPNGBDBM22815(5-iodo-2,3-dihydro-1H-indole-2,3-dione | Isatin-ba...)
Affinity DataIC50:  6.50E+4nMAssay Description:Inhibition of human transglutaminase 2 using Cbz-Gln-Gly as a substrate by GDH-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed