BDBM228245 (S)-3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)-1-(1-(methanesulfonyl)pyrrolidin-3-yl)-1H-imidazo[4,5-c]quinolin-2(3H)-one::US10047084, 28

SMILES Cn1cc(cn1)-c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n([C@H]4CCN(C4)S(C)(=O)=O)c3c2c1

InChI Key InChIKey=DXDMJBHDBWZXBF-IBGZPJMESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 228245   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Beijing Forelandpharma

US Patent
LigandPNGBDBM228245((S)-3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridi...)
Affinity DataIC50: <10nMAssay Description:PI3K alpha-ADP Glo Assay was employed. In the determination of PI3K enzyme activity, the detection kit supplied by Promega (Promega, Cat #: V9101) wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Beijing Forelandpharma

US Patent
LigandPNGBDBM228245((S)-3-methyl-8-(6-(1-methyl-1H-pyrazol-4-yl)pyridi...)
Affinity DataIC50: <10nMAssay Description:The inhibition of the mTOR protein kinase activity by the compounds was determined by the enzymatic activity assay in vitro. The detection kit suppli...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent