BDBM228294 US10047093, 8-11::US10392392, Example 8-11::US10875864, EX. 8-11

SMILES OC[C@H]1CC[C@@H](CC1)Nc1ccc2ncc(-c3cccc(OC(F)(F)F)c3)n2n1

InChI Key InChIKey=ZFSDGASFASUELO-CTYIDZIISA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 228294   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM228294(US10047093, 8-11 | US10392392, Example 8-11 | US10...)
Affinity DataIC50:  8nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM228294(US10047093, 8-11 | US10392392, Example 8-11 | US10...)
Affinity DataIC50: >3.00E+4nMAssay Description:Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM228294(US10047093, 8-11 | US10392392, Example 8-11 | US10...)
Affinity DataIC50: >3.00E+4nMAssay Description:Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China). More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM228294(US10047093, 8-11 | US10392392, Example 8-11 | US10...)
Affinity DataIC50: >3.00E+4nMAssay Description:hERG activity assays representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China). More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM228294(US10047093, 8-11 | US10392392, Example 8-11 | US10...)
Affinity DataIC50:  8nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM228294(US10047093, 8-11 | US10392392, Example 8-11 | US10...)
Affinity DataIC50:  8nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent