BDBM22844 1-[2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)ethyl]-2,3-dihydro-1H-indole-2,3-dione::Isatin-based compound, 64

SMILES O=C1N(CCN2C(=O)C(=O)c3ccccc23)c2ccccc2C1=O

InChI Key InChIKey=ZICIZFBOAQLOTF-UHFFFAOYSA-N

Data  5 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 22844   

TargetCoagulation factor XII(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22844(1-[2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)ethyl]-2...)
Affinity DataKi:  1.54E+3nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22844(1-[2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)ethyl]-2...)
Affinity DataKi:  1.56E+3nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22844(1-[2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)ethyl]-2...)
Affinity DataKi:  6.71E+3nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
St. Jude Research Hospital

LigandPNGBDBM22844(1-[2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)ethyl]-2...)
Affinity DataKi:  1.05E+4nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22844(1-[2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)ethyl]-2...)
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
The Behrend College

Curated by ChEMBL
LigandPNGBDBM22844(1-[2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)ethyl]-2...)
Affinity DataIC50: >1.25E+5nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholinesterase(Equus caballus (Horse))
The Behrend College

Curated by ChEMBL
LigandPNGBDBM22844(1-[2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)ethyl]-2...)
Affinity DataIC50: >1.25E+5nMAssay Description:Inhibition of equine serum BuChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails PubMed