BDBM230365 US9340507, 27.1::US9340507, 27.1A::US9340507, 27.1B

SMILES CC(C)n1cc(C(=O)NCc2ccc(cc2)S(C)=O)c(=O)c(c1C)-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=NQXVUPNEGLZIJR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 230365   

TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM230365(US9340507, 27.1 | US9340507, 27.1A | US9340507, 27...)
Affinity DataIC50:  9nMpH: 7.5 T: 2°CAssay Description:Compound buffer: 100 mM Tris, 500 mM NaCl, adjusted to pH 7.5; Assay buffer: 100 mM Tris, 500 mM NaCl, adjusted to pH 7.5, containing 0.01% BSA. Test...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM230365(US9340507, 27.1 | US9340507, 27.1A | US9340507, 27...)
Affinity DataIC50:  30nMpH: 7.5 T: 2°CAssay Description:Compound buffer: 100 mM Tris, 500 mM NaCl, adjusted to pH 7.5; Assay buffer: 100 mM Tris, 500 mM NaCl, adjusted to pH 7.5, containing 0.01% BSA. Test...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM230365(US9340507, 27.1 | US9340507, 27.1A | US9340507, 27...)
Affinity DataIC50:  5.40nMpH: 7.5 T: 2°CAssay Description:Compound buffer: 100 mM Tris, 500 mM NaCl, adjusted to pH 7.5; Assay buffer: 100 mM Tris, 500 mM NaCl, adjusted to pH 7.5, containing 0.01% BSA. Test...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent