BDBM230803 US9340537, 57::US9896444, Example 57
SMILES FC(F)(Cl)Oc1ccc(NC(=O)c2cnc(N3CCN(CC3)C3CC3)c(c2)-c2ccn[nH]2)cc1
InChI Key InChIKey=FBABBYCCWLCMFO-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 230803
Affinity DataIC50: 5.80nMpH: 7.5 T: 2°CAssay Description:The assay was performed by mixing 10 μL of the compound pre-diluted with 10 μL of ATP (20 μM ATP with 0.1 μCi [γ-33P]-ATP) with the...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Caliper ABL1 (64-515) Assay: The assay plates were prepared by addition of 50 nL per well of compound solution in 90% DMSO. The kinase reactions were...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:Radio ABL1 (64-515) Assay: For determination of ABL kinase activity, the radiometric filter-binding assay was used. The assay was performed by mixing...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMpH: 7.5 T: 2°CAssay Description:The assay plates were prepared by addition of 50 nL per well of compound solution in 90% DMSO. The kinase reactions were started by stepwise addition...More data for this Ligand-Target Pair