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BDBM234599 US9353093, 28

SMILES: CCc1cccc(NC(=O)Nc2csc(c2)-c2cc3ccccc3n2C(N)=O)c1

InChI Key: InChIKey=YDTJZVVELNGMQL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 234599   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234599
PNG
(US9353093, 28)
Show SMILES CCc1cccc(NC(=O)Nc2csc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C22H20N4O2S/c1-2-14-6-5-8-16(10-14)24-22(28)25-17-12-20(29-13-17)19-11-15-7-3-4-9-18(15)26(19)21(23)27/h3-13H,2H2,1H3,(H2,23,27)(H2,24,25,28)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 264n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234599
PNG
(US9353093, 28)
Show SMILES CCc1cccc(NC(=O)Nc2csc(c2)-c2cc3ccccc3n2C(N)=O)c1
Show InChI InChI=1S/C22H20N4O2S/c1-2-14-6-5-8-16(10-14)24-22(28)25-17-12-20(29-13-17)19-11-15-7-3-4-9-18(15)26(19)21(23)27/h3-13H,2H2,1H3,(H2,23,27)(H2,24,25,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 60n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair