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BDBM234602 US9353093, 31

SMILES: NC(=O)n1c(cc2ccccc12)-c1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cs1

InChI Key: InChIKey=LVCMBVIHFUNWCJ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 234602   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234602
PNG
(US9353093, 31)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cs1
Show InChI InChI=1S/C21H14ClF3N4O2S/c22-15-6-5-12(8-14(15)21(23,24)25)27-20(31)28-13-9-18(32-10-13)17-7-11-3-1-2-4-16(11)29(17)19(26)30/h1-10H,(H2,26,30)(H2,27,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 131n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Platelet-derived growth factor subunit B (PDGFB)


(Homo sapiens (Human))
BDBM234602
PNG
(US9353093, 31)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cs1
Show InChI InChI=1S/C21H14ClF3N4O2S/c22-15-6-5-12(8-14(15)21(23,24)25)27-20(31)28-13-9-18(32-10-13)17-7-11-3-1-2-4-16(11)29(17)19(26)30/h1-10H,(H2,26,30)(H2,27,28,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 151n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM234602
PNG
(US9353093, 31)
Show SMILES NC(=O)n1c(cc2ccccc12)-c1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)cs1
Show InChI InChI=1S/C21H14ClF3N4O2S/c22-15-6-5-12(8-14(15)21(23,24)25)27-20(31)28-13-9-18(32-10-13)17-7-11-3-1-2-4-16(11)29(17)19(26)30/h1-10H,(H2,26,30)(H2,27,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 7.35E+3n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium l...


US Patent US9353093 (2016)


BindingDB Entry DOI: 10.7270/Q2BZ64ZV
More data for this
Ligand-Target Pair