BDBM234960 US9556148, 28::n-(cyanomethyl)-4-(2-((4-(4-(2-oxo-1-oxa-8-azaspiro[4.5]decan-8-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)benzamide

SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCC(CC2)N2CCC3(CCC(=O)O3)CC2)n1

InChI Key InChIKey=IGGBMGINFFHJOO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 234960   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

US Patent
LigandPNGBDBM234960(US9556148, 28 | n-(cyanomethyl)-4-(2-((4-(4-(2-oxo...)
Affinity DataIC50:  11nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

US Patent
LigandPNGBDBM234960(US9556148, 28 | n-(cyanomethyl)-4-(2-((4-(4-(2-oxo...)
Affinity DataIC50:  6nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234960(US9556148, 28 | n-(cyanomethyl)-4-(2-((4-(4-(2-oxo...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Cadila Healthcare

US Patent
LigandPNGBDBM234960(US9556148, 28 | n-(cyanomethyl)-4-(2-((4-(4-(2-oxo...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cadila Healthcare

US Patent
LigandPNGBDBM234960(US9556148, 28 | n-(cyanomethyl)-4-(2-((4-(4-(2-oxo...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cadila Healthcare

Curated by ChEMBL
LigandPNGBDBM234960(US9556148, 28 | n-(cyanomethyl)-4-(2-((4-(4-(2-oxo...)
Affinity DataIC50:  55nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent