BDBM23722 4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl-1H-pyrazole::N-Benzoylpyrazole deriv., 30

SMILES Cc1nn(C(=O)c2ccc(Cl)cc2)c(C)c1Cl

InChI Key InChIKey=NTPKEXXMJVFTKE-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 23722   

TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataKi:  1.07E+4nM ΔG°:  -6.78kcal/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:Thrombin activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:Urokinase activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:Kallikrein activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50:  1.28E+4nMAssay Description:Inhibition of human IAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:Cathepsin D assays were monitored with a Fluoroskan Ascent FL microtiter plate reader at excitation and emission wavelengths of 340 and 390 nm, respe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleoside triphosphate diphosphohydrolase 1(Rattus norvegicus)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50:  2.24E+4nMAssay Description:Inhibition of rat NTPDase1 expressed in CHO cells using ATP as substrate preincubated for 10 mins followed by substrate addition measured after 10 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 3(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50:  630nMAssay Description:Inhibition of human NPP3 expressed in COS7 cells using p-nitrophenyl-5'-thymidine monophosphate as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50:  910nMAssay Description:Inhibition of human TNAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Homo sapiens (Human))
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50:  5.34E+3nMAssay Description:Inhibition of human NPP1 expressed in COS7 cells using p-nitrophenyl-5'-thymidine monophosphate as substrate preincubated for 5 to 10 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataIC50:  4.70E+3nMAssay Description:Chymotrypsin activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentrati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
Montana State University

LigandPNGBDBM23722(4-chloro-1-[(4-chlorophenyl)carbonyl]-3,5-dimethyl...)
Affinity DataAssay Description:Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed