BDBM23971 (2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid::Bestatin::CHEMBL29292::Ubenimex
SMILES: CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
InChI Key: InChIKey=VGGGPCQERPFHOB-RDBSUJKOSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute Alsace Curated by ChEMBL | Assay Description Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis | Bioorg Med Chem 20: 4942-53 (2012) Article DOI: 10.1016/j.bmc.2012.06.041 BindingDB Entry DOI: 10.7270/Q2RB75Q1 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Leucine aminopeptidase (Homo sapiens (Human)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wroclaw University of Technology Curated by ChEMBL | Assay Description Binding affinity for cytosolic leucine aminopeptidase (LAP) from porcine kidney | J Med Chem 46: 2641-55 (2003) Article DOI: 10.1021/jm030795v BindingDB Entry DOI: 10.7270/Q27P903F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bacterial leucyl aminopeptidase (Vibrio proteolyticus) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute Alsace Curated by ChEMBL | Assay Description Inhibition of Aeromonas proteolytica leucyl aminopeptidase using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by... | Bioorg Med Chem 21: 6447-55 (2013) Article DOI: 10.1016/j.bmc.2013.08.044 BindingDB Entry DOI: 10.7270/Q2PR7XF2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase B (Rattus norvegicus) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison Curated by ChEMBL | Assay Description Inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver | J Med Chem 32: 1378-92 (1989) Article DOI: 10.1021/jm00126a039 BindingDB Entry DOI: 10.7270/Q20G3KQ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cystinyl aminopeptidase (Rattus norvegicus) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison Curated by ChEMBL | Assay Description Inhibition of leucine aminopeptidase | J Med Chem 32: 1378-92 (1989) Article DOI: 10.1021/jm00126a039 BindingDB Entry DOI: 10.7270/Q20G3KQ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leucine aminopeptidase (Homo sapiens (Human)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibitory activity against Leucine aminopeptidase | J Med Chem 31: 2193-9 (1988) Article DOI: 10.1021/jm00119a022 BindingDB Entry DOI: 10.7270/Q2Z038RM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase B (Rattus norvegicus) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibitory activity against aminopeptidase B | J Med Chem 31: 2193-9 (1988) Article DOI: 10.1021/jm00119a022 BindingDB Entry DOI: 10.7270/Q2Z038RM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Zinc aminopeptidase (Plasmodium falciparum (isolate FcB1 / Columbia)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description Inhibition of Plasmodium falciparum recombinant M1-aminopeptidase expressed in Escherichia coli after 40 mins uisng fluorigenic substrate L-Leucyl-7-... | J Med Chem 54: 1655-66 (2011) Article DOI: 10.1021/jm101227t BindingDB Entry DOI: 10.7270/Q23X86ZX | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Leukotriene A4 hydrolase (Homo sapiens (Human)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Goethe-University Frankfurt Curated by ChEMBL | Assay Description Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-M... | Bioorg Med Chem 24: 5243-5248 (2016) Article DOI: 10.1016/j.bmc.2016.08.047 BindingDB Entry DOI: 10.7270/Q2959KH9 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cytosol aminopeptidase (Bos taurus (bovine)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute Alsace Curated by ChEMBL | Assay Description Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis | Bioorg Med Chem 20: 4942-53 (2012) Article DOI: 10.1016/j.bmc.2012.06.041 BindingDB Entry DOI: 10.7270/Q2RB75Q1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de La Habana Curated by ChEMBL | Assay Description Inhibition of human cytomegalovirus DNA polymerase (95 uL) activity in a solution containing 6.4 mM HEPES (pH 7.5), incubation for 12 minutes at 26 d... | Bioorg Med Chem 25: 4628-4636 (2017) BindingDB Entry DOI: 10.7270/Q2MS3W75 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Mus musculus) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 3.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of mouse APN | ACS Med Chem Lett 3: 959-964 (2012) Article DOI: 10.1021/ml3000758 BindingDB Entry DOI: 10.7270/Q2QJ7JFR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Haute Alsace Curated by ChEMBL | Assay Description Inhibition of porcine kidney APN using L-leucine para-notroanilide as substrate assessed as release of para-nitroaniline by Dixon plot analysis | Bioorg Med Chem 21: 6447-55 (2013) Article DOI: 10.1016/j.bmc.2013.08.044 BindingDB Entry DOI: 10.7270/Q2PR7XF2 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 3.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of porcine kidney microsome aminopeptidase using L-Leu-p-nitroanilide as substrate by Dixon method | Bioorg Med Chem Lett 22: 5863-9 (2012) Article DOI: 10.1016/j.bmcl.2012.07.086 BindingDB Entry DOI: 10.7270/Q2VD70KS | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Leucyl-cystinyl aminopeptidase (Rattus norvegicus) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison Curated by ChEMBL | Assay Description Inhibition of aminopeptidase M or membrane leucine aminopeptidase | J Med Chem 32: 1378-92 (1989) Article DOI: 10.1021/jm00126a039 BindingDB Entry DOI: 10.7270/Q20G3KQ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin Curated by ChEMBL | Assay Description Inhibitory activity against Aminopeptidase M | J Med Chem 31: 2193-9 (1988) Article DOI: 10.1021/jm00119a022 BindingDB Entry DOI: 10.7270/Q2Z038RM | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Oligopeptide transporter, kidney isoform (Rattus norvegicus) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital Curated by ChEMBL | Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells | Pflugers Arch 440: 679-84 (2000) BindingDB Entry DOI: 10.7270/Q2CR5X6C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Oligopeptide transporter small intestine isoform (Homo sapiens (Human)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 4.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Inhibition constant (Ki) for human intestinal peptide carrier | J Med Chem 46: 5725-34 (2003) Article DOI: 10.1021/jm030976x BindingDB Entry DOI: 10.7270/Q22N531C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Solute carrier family 15 member 1 (Rattus norvegicus) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | 1.50E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital Curated by ChEMBL | Assay Description TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT1-expressing LLC-PK1 cells | Pflugers Arch 440: 679-84 (2000) BindingDB Entry DOI: 10.7270/Q2CR5X6C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Homo sapiens (Human)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of aminopeptidase N (unknown origin) | Bioorg Med Chem Lett 23: 4948-52 (2013) Article DOI: 10.1016/j.bmcl.2013.06.058 BindingDB Entry DOI: 10.7270/Q2377B4J | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of pig microsomal aminopeptidase N using L-leu-p-nitroanilide as substrate incubated for 5 mins prior to substrate addition measured after... | Bioorg Med Chem Lett 23: 4948-52 (2013) Article DOI: 10.1016/j.bmcl.2013.06.058 BindingDB Entry DOI: 10.7270/Q2377B4J | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Cytosol aminopeptidase (Bos taurus (bovine)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | 8.0 | 30 |
ENSCMu | Assay Description Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t... | Bioorg Med Chem 14: 7241-57 (2006) Article DOI: 10.1016/j.bmc.2006.06.050 BindingDB Entry DOI: 10.7270/Q2N29V73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bacterial leucyl aminopeptidase (Vibrio proteolyticus) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 8.0 | 30 |
ENSCMu | Assay Description Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t... | Bioorg Med Chem 14: 7241-57 (2006) Article DOI: 10.1016/j.bmc.2006.06.050 BindingDB Entry DOI: 10.7270/Q2N29V73 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ENSCMu | Assay Description Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t... | Bioorg Med Chem 14: 7241-57 (2006) Article DOI: 10.1016/j.bmc.2006.06.050 BindingDB Entry DOI: 10.7270/Q2N29V73 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Leukotriene A4 hydrolase (Homo sapiens (Human)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
ENSCMu | Assay Description Spectrophotometric assays were performed by monitoring hydrolysis of chromogenic substrate. The release of para-nitroaniline at 405 nm was measured t... | Bioorg Med Chem 14: 7241-57 (2006) Article DOI: 10.1016/j.bmc.2006.06.050 BindingDB Entry DOI: 10.7270/Q2N29V73 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase B (Mus musculus) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin | Biochemistry 27: 7301-10 (1988) Article DOI: 10.1021/bi00419a019 BindingDB Entry DOI: 10.7270/Q2SF2TS7 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | 7.2 | n/a |
Shandong University | Assay Description Briefly, the assay was performed in 96-well plates in 50 mm PBS, pH 7.2 as the assay buffer, at 37 °C. The APN solution was mixed with compounds at v... | Chem Biol Drug Des 88: 542-55 (2016) Article DOI: 10.1111/cbdd.12778 BindingDB Entry DOI: 10.7270/Q2HX1BHT | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University | Assay Description The samples and positive controls were serial diluted to various concentrations: 1280 μg/mL, 320 μg/mL, 80 μg/mL, and 20 μg/mL, 5... | J Enzyme Inhib Med Chem 27: 302-10 (2012) Article DOI: 10.3109/14756361003698147 BindingDB Entry DOI: 10.7270/Q2R21083 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.67E+5 | n/a | n/a | n/a | n/a | 8.5 | 25 |
Shandong University | Assay Description The compound samples were assayed for inhibitory activity against MMP-2 in 96-well microplates using succinylated gelatin as the substrate. The compo... | J Enzyme Inhib Med Chem 27: 302-10 (2012) Article DOI: 10.3109/14756361003698147 BindingDB Entry DOI: 10.7270/Q2R21083 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.55E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shandong University | Assay Description IC50 values against APN from Porcine Kidney were determined by using L-Leu-p-nitroanilide as a substrate. All the solutions of the inhibitors were pr... | J Enzyme Inhib Med Chem 28: 545-51 (2013) Article DOI: 10.3109/14756366.2012.656622 BindingDB Entry DOI: 10.7270/Q24J0D1S | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Gelatinase 2 (MMP-2) (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/TrEMBL GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.63E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University | Assay Description Gelatinase A (MMP-2) and TNBS were purchased from Sigma, and the substance was synthesized as described by Vijaykumar et al. The gelatinase, substanc... | J Enzyme Inhib Med Chem 28: 545-51 (2013) Article DOI: 10.3109/14756366.2012.656622 BindingDB Entry DOI: 10.7270/Q24J0D1S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 6.25E+3 | n/a | n/a | n/a | n/a | 7.2 | n/a |
Shandong University | Assay Description IC50 values against APN were determined as previously described and by using L-Leu-p-nitroanilide as a substrate and microsomal aminopeptidase from P... | J Enzyme Inhib Med Chem 28: 717-26 (2013) Article DOI: 10.3109/14756366.2012.680062 BindingDB Entry DOI: 10.7270/Q2930S39 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase (Homo sapiens (Human)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | >4.72E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo Curated by ChEMBL | Assay Description Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line | Bioorg Med Chem Lett 9: 559-62 (1999) Article DOI: 10.1016/s0960-894x(99)00034-7 BindingDB Entry DOI: 10.7270/Q2ZW1MFX | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity against rabbit kidney aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrate | J Med Chem 28: 1158-69 (1985) Article DOI: 10.1021/jm00147a007 BindingDB Entry DOI: 10.7270/Q20C4WB5 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of porcine kidney microsome APN assessed as L-Leu-p-nitroanilide hydrolysis | Bioorg Med Chem 17: 7398-404 (2009) Article DOI: 10.1016/j.bmc.2009.07.014 BindingDB Entry DOI: 10.7270/Q2QV3MMD | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase B (Rattus norvegicus) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | KEGG UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of rat liver aminopeptidase B using 0.2 mM L-leucine-beta-naphthylamide by colorimetry | J Med Chem 20: 510-5 (1977) Article DOI: 10.1021/jm00214a010 BindingDB Entry DOI: 10.7270/Q29W0H11 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of pig kidney microsomal APN using L-Leu-p-nitroanilide as substrate preincubated for 5 mins before substrate addition measured after 30 m... | Bioorg Med Chem 22: 3055-64 (2014) Article DOI: 10.1016/j.bmc.2013.12.025 BindingDB Entry DOI: 10.7270/Q29888JP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of MMP2 (unknown origin) using succinylated gelatin as substrate preincubated for 10 mins before substrate addition measured after 30 mins... | Bioorg Med Chem 22: 3055-64 (2014) Article DOI: 10.1016/j.bmc.2013.12.025 BindingDB Entry DOI: 10.7270/Q29888JP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Lille 2 Curated by ChEMBL | Assay Description Inhibition of microsomal neural aminopeptidase in pig kidney | Bioorg Med Chem 15: 63-76 (2006) Article DOI: 10.1016/j.bmc.2006.10.010 BindingDB Entry DOI: 10.7270/Q23F4P9V | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of pig kidney microsomal aminopeptidase assessed as liberation of p-nitroanilide | Bioorg Med Chem Lett 17: 2935-8 (2007) Article DOI: 10.1016/j.bmcl.2006.12.095 BindingDB Entry DOI: 10.7270/Q2HT2P11 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wroc£?aw University of Technology Curated by ChEMBL | Assay Description Inhibition of pig kidney aminopeptidase N | Bioorg Med Chem Lett 18: 3734-6 (2008) Article DOI: 10.1016/j.bmcl.2008.05.050 BindingDB Entry DOI: 10.7270/Q2H41R6T | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of pig kidney microsomes aminopeptidase N | Bioorg Med Chem 16: 6663-8 (2008) Article DOI: 10.1016/j.bmc.2008.05.081 BindingDB Entry DOI: 10.7270/Q2RB74DK | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of pig kidney microsomal APN | Bioorg Med Chem 17: 2775-84 (2009) Article DOI: 10.1016/j.bmc.2009.02.034 BindingDB Entry DOI: 10.7270/Q29G5MQ0 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of pig kidney microsomal Aminopeptidase N | Bioorg Med Chem 17: 3810-7 (2009) Article DOI: 10.1016/j.bmc.2009.04.038 BindingDB Entry DOI: 10.7270/Q2VT1S0J | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of pig kidney microsome aminopeptidase N by UV-visible spectrophotometer | Bioorg Med Chem 16: 9984-90 (2008) Article DOI: 10.1016/j.bmc.2008.10.025 BindingDB Entry DOI: 10.7270/Q2JQ10VD | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of aminopeptidase N in pig kidney microsome by spectrophotometry | Bioorg Med Chem 17: 4666-73 (2009) Article DOI: 10.1016/j.bmc.2009.04.056 BindingDB Entry DOI: 10.7270/Q2D21XN3 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of pig kidney microsomes aminopeptidase N preincubated for 30 mins | Eur J Med Chem 44: 4819-25 (2009) Article DOI: 10.1016/j.ejmech.2009.07.022 BindingDB Entry DOI: 10.7270/Q2251J73 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University Curated by ChEMBL | Assay Description Inhibition of APN from pig kidney microsomes by spectrophotometry | Bioorg Med Chem 18: 887-95 (2010) Article DOI: 10.1016/j.bmc.2009.11.036 BindingDB Entry DOI: 10.7270/Q2J67H1Z | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 5.87E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Shandong University Curated by ChEMBL | Assay Description Inhibition of porcine kidney microsomal APN after 10 mins at room temperature by spectrophotometry | Bioorg Med Chem 19: 900-6 (2011) Article DOI: 10.1016/j.bmc.2010.11.066 BindingDB Entry DOI: 10.7270/Q2KK9C15 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Aminopeptidase N (Sus scrofa (Pig)) | BDBM23971![]() ((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wroclaw University of Technology Curated by ChEMBL | Assay Description Inhibition of pig kidney aminopeptidase N using Leu-AMC as substrate | Bioorg Med Chem 18: 2930-6 (2010) Article DOI: 10.1016/j.bmc.2010.02.056 BindingDB Entry DOI: 10.7270/Q2FN16C0 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |
Displayed 1 to 50 (of 124 total ) | Next | Last >> |