BDBM239805 Roche-Dataset for PDE10A, Compound 434::US9394311, 88
SMILES Cc1c(Cl)cc(c2nc(CCc3nc(nn3C)N3CCC(F)(F)C3)nn12)C(F)(F)F
InChI Key InChIKey=UNVGETXXYQFUKG-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 239805
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche
F. Hoffmann-La Roche
Affinity DataIC50: 9.78nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche
F. Hoffmann-La Roche
Affinity DataIC50: 9.78nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM M...More data for this Ligand-Target Pair