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BDBM241613 US9409915, 73::US9718820, Compound 73

SMILES: CC(C)(C)c1cc(on1)-c1nc2cc(nc(Cl)c2[nH]1)-c1ccccc1C(F)(F)F

InChI Key: InChIKey=PVPKHMAIMPKPBA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 241613   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241613
PNG
(US9409915, 73 | US9718820, Compound 73)
Show SMILES CC(C)(C)c1cc(on1)-c1nc2cc(nc(Cl)c2[nH]1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H16ClF3N4O/c1-19(2,3)15-9-14(29-28-15)18-26-13-8-12(25-17(21)16(13)27-18)10-6-4-5-7-11(10)20(22,23)24/h4-9H,1-3H3,(H,26,27)
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 28n/an/an/an/an/a25



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, ...


US Patent US9718820 (2017)

More data for this
Ligand-Target Pair
Transient receptor potential M8 protein (TRPM8)


(Canis lupus familiaris (Dog))
BDBM241613
PNG
(US9409915, 73 | US9718820, Compound 73)
Show SMILES CC(C)(C)c1cc(on1)-c1nc2cc(nc(Cl)c2[nH]1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H16ClF3N4O/c1-19(2,3)15-9-14(29-28-15)18-26-13-8-12(25-17(21)16(13)27-18)10-6-4-5-7-11(10)20(22,23)24/h4-9H,1-3H3,(H,26,27)
KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
n/an/a 28n/an/an/an/an/a37



Janssen Pharmaceutica NV

US Patent


Assay Description
HEK293 cells stably expressing canine TRPM8 were routinely grown as monolayers in Dulbecco's minimum essential medium supplemented with 10% FBS, 2 mM...


US Patent US9409915 (2016)


BindingDB Entry DOI: 10.7270/Q23J3BVJ
More data for this
Ligand-Target Pair